Synthesis of Camphor Derivatives. IV

Synthesis and Biological Activities of Camphor Hydrazone and Imine Derivatives

Both sonochemical and classical methodologies have been employed to convert camphor, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-one, C₉H16C=O, into a number of derivatives including hydrazones, C₉H16C=N-NHAr 3, imines, C₉H16C=N-R 7, and the key intermediate nitroimine, C₉H16C=N-NO₂ 6. Reactions of nitroamine 6 with nucleophiles by classical methods provided the desired compounds in a range of yields...

Synthesis of alkynyl-substituted camphor derivatives and their use in the preparation of paclitaxel-related compounds

Compounds containing two alkyne groups in close vicinity at the rigid skeleton of camphorsulfonamide show unique reactivities when treated with electrophiles or catalytic amounts of platinum(II). The formed product structures depend not only on the reagents used but also on the substituents attached to the triple bonds. Cycloisomerisations with perfect atom economy lead to polycyclic heterocycl...

Novel Tricyclic Cyanopyrrolidine Derivatives as Dpp4 Inhibitors: an Improved Synthesis of Tricyclic Α-cycnopyrrolidine from Camphor

An improved multistep synthesis of tricyclic α-cyanopyrrolidine from camphor is presented. The synthesis was carried out by maintaining the cyano group in the form of an amide and its regeneration after the completion of the necessary chemical transformation of a particular functional group. The tricyclic α-cyanopyrrolidine prepared was used to synthesize two novel compounds of DPP4 (Dipeptidyl...

Synthesis of Camphor by the Oxidation of Borneol

Synthesis of Some New Piperazine-iV^iV'-bis-substituted Derivatives As Potential Biologically Active Agents

In a search for new bactericidal and fungicidal agents some new piperazine-TV, TV'-bis-substituted derivatives have been prepared and characterized by their elemental analysis, IR, *H N M R , and mass spectral d a t a . T h e ant ibacter ia l and antifungal activities of all p repared c o m p o u n d s have been determined using Gentamycin as s t a n d a r d antibiotic. Some c o m p o u n d s s...